Therapeutic applications of bronchoalveolar lavage.
نویسندگان
چکیده
The value of bronchoalveolar lavage (BAL) in the exploration and management of interstitial lung diseases is now well-established, and has recently been updated in reports of the European Task group on BAL (1, 2). Its place in therapy is not so clearly demonstrated, although BAL had been used for therapeutic purposes prior to its use as a diagnostic procedure. As early as 1963, RAMIREZ et al. [3) reported on whole lung lavage (WLL) using a large volume of fluid in patients with pulmonary alveolar proteinosis. Since then, this technique has been proposed for removal of any alveolar filling material, in conditions such as alveolar protein os is [ 4, 5], alveolar microlithiasis (6], acute silicosis [7], or accidental inhalation of radioactive particles (8, 9). Its use has also been proposed in obstructive lung diseases [10], to remove the mucous secretions accumulated in the bronchial tree, as in asthma [11, 12], or cystic fibrosis (13, 14). This lavage differs from the segmental BAL currently used for diagnostic or research purposes, in that it is performed under general anaesthesia, and uses a much larger volume of fluid. The actual procedure varies slightly from one centre to another and has not yet been standardized [ 4, 15]. WLL is a safe procedure, as shown by the absence of chronic side-effects over periods as long as 25 yrs in patients treated for alveolar proteinosis [16). On the other hand, its efficacy is known to be dependent on the type of disorder in which it is performed . We will briefly review the main pathological conditions in which WLL is currently performed and will show that alveolar proteinosis is the only disease which clearly profits from WLL. In alJ other conditions mentioned above, the value of WLL is doubtful, or not yet clearly established.
منابع مشابه
First Report on the Isolation of Nocardia Thailandica from the Bronchoalveolar Lavage sample of a Patient in Iran
متن کامل
Comments on \'\'Detection of galactomannan in the bronchoalveolar lavage of high-risk patients with invasive aspergillosis admitted at the intensive care unit\'\' by Khodavaisy et al.
Comments on ''Detection of galactomannan in the bronchoalveolar lavage of high-risk patients with invasive aspergillosis admitted at the intensive care unit'' by Khodavaisy et al. AWT-SEP AWT-SEP AWT-SEP AWT-SEP AWT-SEP AWT-SEP Galactomannan in bronchoalveolar lavage for diagnosis of invasive aspergillosis We rea...
متن کاملThe Value of Bronchoalveolar Lavage in the Diagnosis of Sputum Smear-NegativePulmonary Tuberculosis
Background and Objectives: Sputum smear staining for acid-fast bacilli is initial approach to the diagnosis of pulmonary tuberculosis (PTB) but more than 50% of cases are sputum smear-negative. This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) in patients suspected to have tuberculosis. Methods: This prospective cross-...
متن کاملFirst Report of the Isolation of Nocardia thailandica from the Bronchoalveolar Lavage of a Patient in Iran
Nocardiae are Gram-positive, filamentous, aerobic, relatively slow-growing, and weakly acid-fast bacteria which cause nocardiosis in humans. We describe a 53-year-old patient with chronic bronchitis referred to Al-Zahra Hospital, Isfahan. A bronchial washing sample was taken from the patient. A Nocardia-like microorganism was detected in microscopic evaluation. Based on the phenotypic and 16S r...
متن کاملThe effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats
Objective(s):To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats. Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 ...
متن کاملIdentification and Antifungal Susceptibility Testing of Candida species isolated from Bronchoalveolar Lavage sampl
The frequency of fungal infections in immunocompromised patients, particularly by Candida species, has increased in recent years. Colonization by Candida species in respiratory tract in susceptible hosts may play an important role to precede disseminated candidiasis. This study was designed to identify Candida species from bronchoalveolar lavage (BAL) samples and determination of antifungal sus...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The European respiratory journal
دوره 5 10 شماره
صفحات -
تاریخ انتشار 1992